שלח לחבר תודה לך על המלצתך על e-Med לחבר

	01/08/2021

27/08/2020

הערכת תוצאות טיפול Andexanet Alfa מול 4F-PCC במקרים של דמם תוך-גולגולתי על-רקע קסרלטו ואליקוויס (J Thromb Haemost)

36<P class=MsoNormal style="MARGIN: 0cm 0cm 0pt" dir=rtl><SPAN lang=HE style='FONT-FAMILY: "Arial","sans-serif"; mso-ascii-font-family: Calibri; mso-ascii-theme-font: minor-latin; mso-hansi-font-family: Calibri; mso-hansi-theme-font: minor-latin; mso-bidi-font-family: Arial; mso-bidi-theme-font: minor-bidi'><?xml:namespace prefix = "o" ns = "urn:schemas-microsoft-com:office:office" /><o:p> </o:p></SPAN></P> <P class=MsoNormal style="MARGIN: 0cm 0cm 0pt" dir=rtl><SPAN lang=HE style='FONT-FAMILY: "Arial","sans-serif"; mso-ascii-font-family: Calibri; mso-ascii-theme-font: minor-latin; mso-hansi-font-family: Calibri; mso-hansi-theme-font: minor-latin; mso-bidi-font-family: Arial; mso-bidi-theme-font: minor-bidi'>במאמר שפורסם בכתב העת </SPAN><FONT face=Calibri><SPAN dir=ltr>Journal of Thrombosis and Haemostasis</SPAN><SPAN dir=rtl></SPAN></FONT><SPAN lang=HE style='FONT-FAMILY: "Arial","sans-serif"; mso-ascii-font-family: Calibri; mso-ascii-theme-font: minor-latin; mso-hansi-font-family: Calibri; mso-hansi-theme-font: minor-latin; mso-bidi-font-family: Arial; mso-bidi-theme-font: minor-bidi'><SPAN dir=rtl></SPAN> מדווחים חוקרים מבוסטון על תוצאות מחקר חדש, מהן עולה כי שיעורי גבוהים יותר של המוסטאזיס טוב או מצוין ומדד </SPAN><FONT face=Calibri><SPAN dir=ltr>GOS</SPAN><SPAN dir=rtl></SPAN></FONT><SPAN lang=HE style='FONT-FAMILY: "Arial","sans-serif"; mso-ascii-font-family: Calibri; mso-ascii-theme-font: minor-latin; mso-hansi-font-family: Calibri; mso-hansi-theme-font: minor-latin; mso-bidi-font-family: Arial; mso-bidi-theme-font: minor-bidi'><SPAN dir=rtl></SPAN> (</SPAN><FONT face=Calibri><SPAN dir=ltr>Glasgow Outcome Score</SPAN><SPAN dir=rtl></SPAN></FONT><SPAN lang=HE style='FONT-FAMILY: "Arial","sans-serif"; mso-ascii-font-family: Calibri; mso-ascii-theme-font: minor-latin; mso-hansi-font-family: Calibri; mso-hansi-theme-font: minor-latin; mso-bidi-font-family: Arial; mso-bidi-theme-font: minor-bidi'><SPAN dir=rtl></SPAN>) של מעל 3 נקודות בעת השחרור מבית החולים והיארעות גבוהה יותר של תרומבוזיס בחולים שטופלו ב-</SPAN><FONT face=Calibri><SPAN dir=ltr>Andexanet Alfa</SPAN><SPAN dir=rtl></SPAN></FONT><SPAN lang=HE style='FONT-FAMILY: "Arial","sans-serif"; mso-ascii-font-family: Calibri; mso-ascii-theme-font: minor-latin; mso-hansi-font-family: Calibri; mso-hansi-theme-font: minor-latin; mso-bidi-font-family: Arial; mso-bidi-theme-font: minor-bidi'><SPAN dir=rtl></SPAN>, בהשוואה לאלו שקיבלו </SPAN><SPAN dir=ltr></SPAN><SPAN dir=ltr><SPAN dir=ltr></SPAN><FONT face=Calibri>4F-PCC</FONT></SPAN><SPAN dir=rtl></SPAN><SPAN lang=HE style='FONT-FAMILY: "Arial","sans-serif"; mso-ascii-font-family: Calibri; mso-ascii-theme-font: minor-latin; mso-hansi-font-family: Calibri; mso-hansi-theme-font: minor-latin; mso-bidi-font-family: Arial; mso-bidi-theme-font: minor-bidi'><SPAN dir=rtl></SPAN> (</SPAN><SPAN dir=ltr></SPAN><SPAN dir=ltr><SPAN dir=ltr></SPAN><FONT face=Calibri>4 Factor Prothrombin Complex Concentrate</FONT></SPAN><SPAN dir=rtl></SPAN><SPAN lang=HE style='FONT-FAMILY: "Arial","sans-serif"; mso-ascii-font-family: Calibri; mso-ascii-theme-font: minor-latin; mso-hansi-font-family: Calibri; mso-hansi-theme-font: minor-latin; mso-bidi-font-family: Arial; mso-bidi-theme-font: minor-bidi'><SPAN dir=rtl></SPAN>) להסגת פעילות מעכב פומי של פקטור </SPAN><FONT face=Calibri><SPAN dir=ltr>Xa</SPAN><SPAN dir=rtl></SPAN></FONT><SPAN lang=HE style='FONT-FAMILY: "Arial","sans-serif"; mso-ascii-font-family: Calibri; mso-ascii-theme-font: minor-latin; mso-hansi-font-family: Calibri; mso-hansi-theme-font: minor-latin; mso-bidi-font-family: Arial; mso-bidi-theme-font: minor-bidi'><SPAN dir=rtl></SPAN>. <SPAN style="mso-spacerun: yes"> </SPAN>עם זאת, בקרב מטופלים ב-</SPAN><SPAN dir=ltr></SPAN><SPAN dir=ltr><SPAN dir=ltr></SPAN><FONT face=Calibri>4F-PCC</FONT></SPAN><SPAN dir=rtl></SPAN><SPAN lang=HE style='FONT-FAMILY: "Arial","sans-serif"; mso-ascii-font-family: Calibri; mso-ascii-theme-font: minor-latin; mso-hansi-font-family: Calibri; mso-hansi-theme-font: minor-latin; mso-bidi-font-family: Arial; mso-bidi-theme-font: minor-bidi'><SPAN dir=rtl></SPAN> תועדו מדדי </SPAN><FONT face=Calibri><SPAN dir=ltr>GCS</SPAN><SPAN dir=rtl></SPAN></FONT><SPAN lang=HE style='FONT-FAMILY: "Arial","sans-serif"; mso-ascii-font-family: Calibri; mso-ascii-theme-font: minor-latin; mso-hansi-font-family: Calibri; mso-hansi-theme-font: minor-latin; mso-bidi-font-family: Arial; mso-bidi-theme-font: minor-bidi'><SPAN dir=rtl></SPAN> (</SPAN><FONT face=Calibri><SPAN dir=ltr>Glasgow Coma Scale</SPAN><SPAN dir=rtl></SPAN></FONT><SPAN lang=HE style='FONT-FAMILY: "Arial","sans-serif"; mso-ascii-font-family: Calibri; mso-ascii-theme-font: minor-latin; mso-hansi-font-family: Calibri; mso-hansi-theme-font: minor-latin; mso-bidi-font-family: Arial; mso-bidi-theme-font: minor-bidi'><SPAN dir=rtl></SPAN>) ונפח דימום תוך-גולגולתי נמוכים יותר טרם הטיפול.<o:p></o:p></SPAN></P> <P class=MsoNormal style="MARGIN: 0cm 0cm 0pt" dir=rtl><SPAN lang=HE style='FONT-FAMILY: "Arial","sans-serif"; mso-ascii-font-family: Calibri; mso-ascii-theme-font: minor-latin; mso-hansi-font-family: Calibri; mso-hansi-theme-font: minor-latin; mso-bidi-font-family: Arial; mso-bidi-theme-font: minor-bidi'><o:p> </o:p></SPAN></P> <P class=MsoNormal style="MARGIN: 0cm 0cm 0pt" dir=rtl><SPAN lang=HE style='FONT-FAMILY: "Arial","sans-serif"; mso-ascii-font-family: Calibri; mso-ascii-theme-font: minor-latin; mso-hansi-font-family: Calibri; mso-hansi-theme-font: minor-latin; mso-bidi-font-family: Arial; mso-bidi-theme-font: minor-bidi'>במסגרת המחקר ביקשו החוקרים לבחון את תוצאות הטיפול ב-</SPAN><FONT face=Calibri><SPAN dir=ltr>Andexanet Alfa</SPAN><SPAN dir=rtl></SPAN></FONT><SPAN lang=HE style='FONT-FAMILY: "Arial","sans-serif"; mso-ascii-font-family: Calibri; mso-ascii-theme-font: minor-latin; mso-hansi-font-family: Calibri; mso-hansi-theme-font: minor-latin; mso-bidi-font-family: Arial; mso-bidi-theme-font: minor-bidi'><SPAN dir=rtl></SPAN> או </SPAN><SPAN dir=ltr></SPAN><SPAN dir=ltr><SPAN dir=ltr></SPAN><FONT face=Calibri>4F-PCC</FONT></SPAN><SPAN dir=rtl></SPAN><SPAN lang=HE style='FONT-FAMILY: "Arial","sans-serif"; mso-ascii-font-family: Calibri; mso-ascii-theme-font: minor-latin; mso-hansi-font-family: Calibri; mso-hansi-theme-font: minor-latin; mso-bidi-font-family: Arial; mso-bidi-theme-font: minor-bidi'><SPAN dir=rtl></SPAN> במקרים של דימום תוך-גולגולתי על-רקע מעכב פקטור </SPAN><FONT face=Calibri><SPAN dir=ltr>Xa</SPAN><SPAN dir=rtl></SPAN></FONT><SPAN lang=HE style='FONT-FAMILY: "Arial","sans-serif"; mso-ascii-font-family: Calibri; mso-ascii-theme-font: minor-latin; mso-hansi-font-family: Calibri; mso-hansi-theme-font: minor-latin; mso-bidi-font-family: Arial; mso-bidi-theme-font: minor-bidi'><SPAN dir=rtl></SPAN>. הם השלימו מחקר רטרוספקטיבי, שכלל מקרים של דימום תוך-גולגולתי על-רקע טיפול ב-</SPAN><A href="http://drug.co.il/bygeneric.asp?gen_id=3636&drugID=9169"><FONT color=#0000ff><FONT face=Calibri><SPAN dir=ltr>Rivaroxaban</SPAN><SPAN dir=rtl></SPAN></FONT><SPAN lang=HE style='FONT-FAMILY: "Arial","sans-serif"; mso-ascii-font-family: Calibri; mso-ascii-theme-font: minor-latin; mso-hansi-font-family: Calibri; mso-hansi-theme-font: minor-latin; mso-bidi-font-family: Arial; mso-bidi-theme-font: minor-bidi'><SPAN dir=rtl></SPAN> (קסרלטו)</SPAN></FONT></A><SPAN lang=HE style='FONT-FAMILY: "Arial","sans-serif"; mso-ascii-font-family: Calibri; mso-ascii-theme-font: minor-latin; mso-hansi-font-family: Calibri; mso-hansi-theme-font: minor-latin; mso-bidi-font-family: Arial; mso-bidi-theme-font: minor-bidi'> או </SPAN><A href="http://drug.co.il/bygeneric.asp?gen_id=3402&drugID=9926"><FONT color=#0000ff><FONT face=Calibri><SPAN dir=ltr>Apixaban</SPAN><SPAN dir=rtl></SPAN></FONT><SPAN lang=HE style='FONT-FAMILY: "Arial","sans-serif"; mso-ascii-font-family: Calibri; mso-ascii-theme-font: minor-latin; mso-hansi-font-family: Calibri; mso-hansi-theme-font: minor-latin; mso-bidi-font-family: Arial; mso-bidi-theme-font: minor-bidi'><SPAN dir=rtl></SPAN> (אליקוויס)</SPAN></FONT></A><SPAN lang=HE style='FONT-FAMILY: "Arial","sans-serif"; mso-ascii-font-family: Calibri; mso-ascii-theme-font: minor-latin; mso-hansi-font-family: Calibri; mso-hansi-theme-font: minor-latin; mso-bidi-font-family: Arial; mso-bidi-theme-font: minor-bidi'> בין השנים 2016-2019, אשר טופלו ב-</SPAN><FONT face=Calibri><SPAN dir=ltr>Andexanet Alfa</SPAN><SPAN dir=rtl></SPAN></FONT><SPAN lang=HE style='FONT-FAMILY: "Arial","sans-serif"; mso-ascii-font-family: Calibri; mso-ascii-theme-font: minor-latin; mso-hansi-font-family: Calibri; mso-hansi-theme-font: minor-latin; mso-bidi-font-family: Arial; mso-bidi-theme-font: minor-bidi'><SPAN dir=rtl></SPAN> או </SPAN><SPAN dir=ltr></SPAN><SPAN dir=ltr><SPAN dir=ltr></SPAN><FONT face=Calibri>4F-PCC</FONT></SPAN><SPAN dir=rtl></SPAN><SPAN lang=HE style='FONT-FAMILY: "Arial","sans-serif"; mso-ascii-font-family: Calibri; mso-ascii-theme-font: minor-latin; mso-hansi-font-family: Calibri; mso-hansi-theme-font: minor-latin; mso-bidi-font-family: Arial; mso-bidi-theme-font: minor-bidi'><SPAN dir=rtl></SPAN>. הם בחנו את שיעורי המוסטאזיס טוב או מצויין, מצב תפקודי טוב (מדד </SPAN><FONT face=Calibri><SPAN dir=ltr>GOS</SPAN><SPAN dir=rtl></SPAN></FONT><SPAN lang=HE style='FONT-FAMILY: "Arial","sans-serif"; mso-ascii-font-family: Calibri; mso-ascii-theme-font: minor-latin; mso-hansi-font-family: Calibri; mso-hansi-theme-font: minor-latin; mso-bidi-font-family: Arial; mso-bidi-theme-font: minor-bidi'><SPAN dir=rtl></SPAN> של מעל 3 נקודות) בעת השחרור מבית החולים והיארעות תרומבוזיס בתוך 30 ימים. <o:p></o:p></SPAN></P> <P class=MsoNormal style="MARGIN: 0cm 0cm 0pt" dir=rtl><SPAN lang=HE style='FONT-FAMILY: "Arial","sans-serif"; mso-ascii-font-family: Calibri; mso-ascii-theme-font: minor-latin; mso-hansi-font-family: Calibri; mso-hansi-theme-font: minor-latin; mso-bidi-font-family: Arial; mso-bidi-theme-font: minor-bidi'><o:p> </o:p></SPAN></P> <P class=MsoNormal style="MARGIN: 0cm 0cm 0pt" dir=rtl><SPAN lang=HE style='FONT-FAMILY: "Arial","sans-serif"; mso-ascii-font-family: Calibri; mso-ascii-theme-font: minor-latin; mso-hansi-font-family: Calibri; mso-hansi-theme-font: minor-latin; mso-bidi-font-family: Arial; mso-bidi-theme-font: minor-bidi'>מדגם המחקר כלל 18 חולים שטופלו ב-</SPAN><FONT face=Calibri><SPAN dir=ltr>Andexanet Alfa</SPAN><SPAN dir=rtl></SPAN></FONT><SPAN lang=HE style='FONT-FAMILY: "Arial","sans-serif"; mso-ascii-font-family: Calibri; mso-ascii-theme-font: minor-latin; mso-hansi-font-family: Calibri; mso-hansi-theme-font: minor-latin; mso-bidi-font-family: Arial; mso-bidi-theme-font: minor-bidi'><SPAN dir=rtl></SPAN> ו-11 חולים שטופלו ב-</SPAN><SPAN dir=ltr></SPAN><SPAN dir=ltr><SPAN dir=ltr></SPAN><FONT face=Calibri>4F-PCC</FONT></SPAN><SPAN dir=rtl></SPAN><SPAN lang=HE style='FONT-FAMILY: "Arial","sans-serif"; mso-ascii-font-family: Calibri; mso-ascii-theme-font: minor-latin; mso-hansi-font-family: Calibri; mso-hansi-theme-font: minor-latin; mso-bidi-font-family: Arial; mso-bidi-theme-font: minor-bidi'><SPAN dir=rtl></SPAN>. המוסטאזיס טוב או מצוין תועד ב-88.9% מהמטופלים ב-</SPAN><FONT face=Calibri><SPAN dir=ltr>Andexanet Alfa</SPAN><SPAN dir=rtl></SPAN></FONT><SPAN lang=HE style='FONT-FAMILY: "Arial","sans-serif"; mso-ascii-font-family: Calibri; mso-ascii-theme-font: minor-latin; mso-hansi-font-family: Calibri; mso-hansi-theme-font: minor-latin; mso-bidi-font-family: Arial; mso-bidi-theme-font: minor-bidi'><SPAN dir=rtl></SPAN> וב-60% מהמטופלים ב-</SPAN><SPAN dir=ltr></SPAN><SPAN dir=ltr><SPAN dir=ltr></SPAN><FONT face=Calibri>4F-PCC</FONT></SPAN><SPAN dir=rtl></SPAN><SPAN lang=HE style='FONT-FAMILY: "Arial","sans-serif"; mso-ascii-font-family: Calibri; mso-ascii-theme-font: minor-latin; mso-hansi-font-family: Calibri; mso-hansi-theme-font: minor-latin; mso-bidi-font-family: Arial; mso-bidi-theme-font: minor-bidi'><SPAN dir=rtl></SPAN>. תוצאו תפקודיות טובות בעת השחרור מבית החולים תועדו ב-55.6% מהמטופלים ב-</SPAN><FONT face=Calibri><SPAN dir=ltr>Andexanet Alfa</SPAN><SPAN dir=rtl></SPAN></FONT><SPAN lang=HE style='FONT-FAMILY: "Arial","sans-serif"; mso-ascii-font-family: Calibri; mso-ascii-theme-font: minor-latin; mso-hansi-font-family: Calibri; mso-hansi-theme-font: minor-latin; mso-bidi-font-family: Arial; mso-bidi-theme-font: minor-bidi'><SPAN dir=rtl></SPAN> וב-9.1% מהמטופלים ב-</SPAN><SPAN dir=ltr></SPAN><SPAN dir=ltr><SPAN dir=ltr></SPAN><FONT face=Calibri>4F-PCC</FONT></SPAN><SPAN dir=rtl></SPAN><SPAN lang=HE style='FONT-FAMILY: "Arial","sans-serif"; mso-ascii-font-family: Calibri; mso-ascii-theme-font: minor-latin; mso-hansi-font-family: Calibri; mso-hansi-theme-font: minor-latin; mso-bidi-font-family: Arial; mso-bidi-theme-font: minor-bidi'><SPAN dir=rtl></SPAN>.<o:p></o:p></SPAN></P> <P class=MsoNormal style="MARGIN: 0cm 0cm 0pt" dir=rtl><SPAN lang=HE style='FONT-FAMILY: "Arial","sans-serif"; mso-ascii-font-family: Calibri; mso-ascii-theme-font: minor-latin; mso-hansi-font-family: Calibri; mso-hansi-theme-font: minor-latin; mso-bidi-font-family: Arial; mso-bidi-theme-font: minor-bidi'><o:p> </o:p></SPAN></P> <P class=MsoNormal style="MARGIN: 0cm 0cm 0pt" dir=rtl><SPAN lang=HE style='FONT-FAMILY: "Arial","sans-serif"; mso-ascii-font-family: Calibri; mso-ascii-theme-font: minor-latin; mso-hansi-font-family: Calibri; mso-hansi-theme-font: minor-latin; mso-bidi-font-family: Arial; mso-bidi-theme-font: minor-bidi'>חציון מרווח הזמן בין ההוראה ועד המתן עמד על 1.1 שעות, בהשוואה ל-0.5 שעות בקבוצת הטיפול ב-</SPAN><FONT face=Calibri><SPAN dir=ltr>Andexanet Alfa</SPAN><SPAN dir=rtl></SPAN></FONT><SPAN lang=HE style='FONT-FAMILY: "Arial","sans-serif"; mso-ascii-font-family: Calibri; mso-ascii-theme-font: minor-latin; mso-hansi-font-family: Calibri; mso-hansi-theme-font: minor-latin; mso-bidi-font-family: Arial; mso-bidi-theme-font: minor-bidi'><SPAN dir=rtl></SPAN> ו-</SPAN><SPAN dir=ltr></SPAN><SPAN dir=ltr><SPAN dir=ltr></SPAN><FONT face=Calibri>4F-PCC</FONT></SPAN><SPAN dir=rtl></SPAN><SPAN lang=HE style='FONT-FAMILY: "Arial","sans-serif"; mso-ascii-font-family: Calibri; mso-ascii-theme-font: minor-latin; mso-hansi-font-family: Calibri; mso-hansi-theme-font: minor-latin; mso-bidi-font-family: Arial; mso-bidi-theme-font: minor-bidi'><SPAN dir=rtl></SPAN>, בהתאמה. חציון עלות הטיפול ב-</SPAN><FONT face=Calibri><SPAN dir=ltr>Andexanet Alfa</SPAN><SPAN dir=rtl></SPAN></FONT><SPAN style='FONT-FAMILY: "Arial","sans-serif"; mso-ascii-font-family: Calibri; mso-ascii-theme-font: minor-latin; mso-hansi-font-family: Calibri; mso-hansi-theme-font: minor-latin; mso-bidi-font-family: Arial; mso-bidi-theme-font: minor-bidi'><SPAN dir=rtl></SPAN> <SPAN lang=HE>עמד על 29,970 דולרים למטופל, בהשוואה לחציון עלות של 6,925 דולרים למטופל עם </SPAN></SPAN><SPAN dir=ltr></SPAN><SPAN dir=ltr><SPAN dir=ltr></SPAN><FONT face=Calibri>4F-PCC</FONT></SPAN><SPAN dir=rtl></SPAN><SPAN lang=HE style='FONT-FAMILY: "Arial","sans-serif"; mso-ascii-font-family: Calibri; mso-ascii-theme-font: minor-latin; mso-hansi-font-family: Calibri; mso-hansi-theme-font: minor-latin; mso-bidi-font-family: Arial; mso-bidi-theme-font: minor-bidi'><SPAN dir=rtl></SPAN>. <o:p></o:p></SPAN></P> <P class=MsoNormal style="MARGIN: 0cm 0cm 0pt" dir=rtl><SPAN lang=HE style='FONT-FAMILY: "Arial","sans-serif"; mso-ascii-font-family: Calibri; mso-ascii-theme-font: minor-latin; mso-hansi-font-family: Calibri; mso-hansi-theme-font: minor-latin; mso-bidi-font-family: Arial; mso-bidi-theme-font: minor-bidi'><o:p> </o:p></SPAN></P> <P class=MsoNormal style="MARGIN: 0cm 0cm 0pt" dir=rtl><SPAN lang=HE style='FONT-FAMILY: "Arial","sans-serif"; mso-ascii-font-family: Calibri; mso-ascii-theme-font: minor-latin; mso-hansi-font-family: Calibri; mso-hansi-theme-font: minor-latin; mso-bidi-font-family: Arial; mso-bidi-theme-font: minor-bidi'>ממצאי המחקר מעידים על שיעורים גבוהים יותר של המוסטאזיס טוב או מצוין ומדד </SPAN><FONT face=Calibri><SPAN dir=ltr>GOS</SPAN><SPAN dir=rtl></SPAN></FONT><SPAN lang=HE style='FONT-FAMILY: "Arial","sans-serif"; mso-ascii-font-family: Calibri; mso-ascii-theme-font: minor-latin; mso-hansi-font-family: Calibri; mso-hansi-theme-font: minor-latin; mso-bidi-font-family: Arial; mso-bidi-theme-font: minor-bidi'><SPAN dir=rtl></SPAN> של מעל 3 נקודות בעת השחרור מבית החולים, עם היארעות גבוהה יותר של תרומבוזיס בחולים שטופלו ב-</SPAN><FONT face=Calibri><SPAN dir=ltr>Andexanet Alfa</SPAN><SPAN dir=rtl></SPAN></FONT><SPAN lang=HE style='FONT-FAMILY: "Arial","sans-serif"; mso-ascii-font-family: Calibri; mso-ascii-theme-font: minor-latin; mso-hansi-font-family: Calibri; mso-hansi-theme-font: minor-latin; mso-bidi-font-family: Arial; mso-bidi-theme-font: minor-bidi'><SPAN dir=rtl></SPAN>, בהשוואה ל-</SPAN><SPAN dir=ltr></SPAN><SPAN dir=ltr><SPAN dir=ltr></SPAN><FONT face=Calibri>4F-PCC</FONT></SPAN><SPAN dir=rtl></SPAN><SPAN lang=HE style='FONT-FAMILY: "Arial","sans-serif"; mso-ascii-font-family: Calibri; mso-ascii-theme-font: minor-latin; mso-hansi-font-family: Calibri; mso-hansi-theme-font: minor-latin; mso-bidi-font-family: Arial; mso-bidi-theme-font: minor-bidi'><SPAN dir=rtl></SPAN> להסגת פעילות מעכב פומי של פקטור </SPAN><FONT face=Calibri><SPAN dir=ltr>Xa</SPAN><SPAN dir=rtl></SPAN></FONT><SPAN lang=HE style='FONT-FAMILY: "Arial","sans-serif"; mso-ascii-font-family: Calibri; mso-ascii-theme-font: minor-latin; mso-hansi-font-family: Calibri; mso-hansi-theme-font: minor-latin; mso-bidi-font-family: Arial; mso-bidi-theme-font: minor-bidi'><SPAN dir=rtl></SPAN>. <o:p></o:p></SPAN></P> <P class=MsoNormal style="MARGIN: 0cm 0cm 0pt" dir=rtl><SPAN lang=HE style='FONT-FAMILY: "Arial","sans-serif"; mso-ascii-font-family: Calibri; mso-ascii-theme-font: minor-latin; mso-hansi-font-family: Calibri; mso-hansi-theme-font: minor-latin; mso-bidi-font-family: Arial; mso-bidi-theme-font: minor-bidi'><o:p> </o:p></SPAN></P> <P class=MsoNormal style="MARGIN: 0cm 0cm 0pt" dir=rtl><A href="https://onlinelibrary.wiley.com/doi/abs/10.1111/jth.14838"><SPAN dir=ltr><FONT color=#0000ff face=Calibri>J Thromb Haemost. 2020;18(7):1637-1647</FONT></SPAN></A><SPAN lang=HE style='FONT-FAMILY: "Arial","sans-serif"; mso-ascii-font-family: Calibri; mso-ascii-theme-font: minor-latin; mso-hansi-font-family: Calibri; mso-hansi-theme-font: minor-latin; mso-bidi-font-family: Arial; mso-bidi-theme-font: minor-bidi'><o:p></o:p></SPAN></P> <P class=MsoNormal style="MARGIN: 0cm 0cm 0pt" dir=rtl><SPAN lang=HE style='FONT-FAMILY: "Arial","sans-serif"; mso-ascii-font-family: Calibri; mso-ascii-theme-font: minor-latin; mso-hansi-font-family: Calibri; mso-hansi-theme-font: minor-latin; mso-bidi-font-family: Arial; mso-bidi-theme-font: minor-bidi'><o:p> </o:p></SPAN></P> <P class=MsoNormal style="MARGIN: 0cm 0cm 0pt" dir=rtl><SPAN lang=HE style='FONT-FAMILY: "Arial","sans-serif"; mso-ascii-font-family: Calibri; mso-ascii-theme-font: minor-latin; mso-hansi-font-family: Calibri; mso-hansi-theme-font: minor-latin; mso-bidi-font-family: Arial; mso-bidi-theme-font: minor-bidi'><o:p> </o:p></SPAN></P> <P class=MsoNormal style="MARGIN: 0cm 0cm 0pt" dir=rtl><SPAN lang=HE style='FONT-FAMILY: "Arial","sans-serif"; mso-ascii-font-family: Calibri; mso-ascii-theme-font: minor-latin; mso-hansi-font-family: Calibri; mso-hansi-theme-font: minor-latin; mso-bidi-font-family: Arial; mso-bidi-theme-font: minor-bidi'><o:p> </o:p></SPAN></P>

כתובת נמען
נושא
שמך
כתובת הדואר שלך
הערה
	סגור חלון