Moderate analgesic use not associated with renal failure in healthy men

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Last Updated: 2001-07-17 16:00:14 EDT (Reuters Health)

WESTPORT, CT (Reuters Health) – The moderate use of analgesics does not appear to be associated with an increased risk of renal failure in healthy men, according to a report in The Journal of the American Medical Association for July 18.

Using data from the Physician's Health Study, Dr. J. Michael Gaziano from Brigham and Women's Hospital in Boston and colleagues analyzed blood samples and self-reports of analgesic use for 11,032 initially healthy men.

The researchers found that 460 (4.2%) of the men had elevated creatinine levels and 1258 (11.4%) had reduced creatinine clearances. However, these measurements were similar for men who used analgesics and those who did not. This was true even for men who took 2500 or more pills over the 14 years of follow-up.

Among men who took 2500 pills or more, the adjusted relative risk of increased creatinine levels was 0.83 for acetaminophen (P for trend = .05); 0.98 for aspirin (P for trend = .96); and 1.07 for other nonsteroidal anti-inflammatory drugs (P for trend = .86). "No association was observed between analgesic use and reduced creatinine clearance," Dr. Gaziano's group reports.

This study "provides reassuring evidence that there does not appear to be a strong association between chronic analgesic use and chronic renal dysfunction among a large cohort of men," the investigators conclude.

Other studies that have found such an association, the researchers suggest, may have suffered from the "limitations inherent in the case-control design."

JAMA 2001;286:315-321.

-Westport Newsroom 203 319 2700

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