AMP challenge helps evaluate inflammation in asthma

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Last Updated: 2001-07-24 13:49:43 EDT (Reuters Health)

WESTPORT, CT (Reuters Health) – Responsiveness to airway challenge with adenosine 5'-monophosphate (AMP) provides a better reflection of airway inflammation than does challenge with methacholine, according to Dutch researchers.

As reported in the June issue of the American Journal of Respiratory and Critical Care Medicine, Dr. Dirkje S. Postma and colleagues, from University Hospital Groningen studied 120 mild to moderate atopic asthmatics who underwent spirometry, sputum induction, blood sampling and other testing. Also measured was PC20, the concentration of AMP or methacholine required to cause a 20% drop in lung function (FEV1).

Analysis showed that PC20 methacholine was "predominantly predicted" by FEV1 percent predicted. The percentage of peripheral blood monocytes was "a weak additional independent predictor." Conversely, PC20 AMP was predominantly predicted by the percentage of eosinophils in sputum. FEV1 percent predicted "was only an additional independent predictor."

In light of these findings, the researchers conclude that, "PC20 AMP reflects more closely the extent of airway inflammation due to asthma than PC20 methacholine."

Am J Respir Crit Care Med 2001;163:1546-1550.

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