Hypertension linked with decreased bone mineral density in women

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Last Updated: 2001-07-24 12:14:58 EDT (Reuters Health)

WESTPORT, CT (Reuters Health) – Compared with women who have normal blood pressure, women with untreated hypertension have decreased bone mineral density (BMD) in the lumbar spine, according to a report in the July issue of the American Journal of Hypertension.

Using dual-energy X-ray absorptiometric (DXA), Dr. Kazushi Tsuda, of the Wakayama Medical University, in Japan, and colleagues measured BMD in 31 women with untreated essential hypertension and in 14 normotensive controls. All of the women were middle-aged.

"From a sample of 15 female hypertensive subjects and 11 female normotensive subjects, the 24-h urine collection was obtained for determination of calcium excretion," the researchers explain. They used regression analysis to examine the association between BMD and both systolic blood pressure and the 24-h urinary calcium/sodium ratio.

The investigators found no differences between hypertensive and normotensive subjects in serum total calcium, total magnesium, ionized calcium, and 1,25(OH)2 vitamin D.

However, DXA analysis showed that hypertensive women had a significant decrease in BMD in the lumbar spine compared with normotensive women. "In addition, the BMD was inversely correlated with systolic blood pressure."

Female hypertensive subjects had a significantly higher 24-h urinary calcium (mmol)/sodium (mmol) ratio than female normotensive patients, at 3.10 and 2.04, respectively. "Furthermore, the greater the calcium/sodium ratio, the lower the BMD in women," the team explains.

Based on these findings, Dr. Tsuda and colleagues hypothesize that "high blood pressure might be associated with reduced BMD in female hypertensive subjects."

Am J Hypertens 2001;14:704-707.

-Westport Newsroom 203 319 2700

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