המידע באדיבות מדיקונטקסט
Last Updated: 2001-07-30 13:52:16 EDT (Reuters Health)
By Will Boggs, MD
LONDON (Reuters Health) – The use of estrogen in oral contraceptives and hormone replacement therapy (HRT) does not increase the risk of asthma and asthma-like symptoms, according to a report in the August issue of Thorax.
Dr. Peter Lange from Bispebjerg University Hospital in Copenhagen and colleagues used data from the Copenhagen City Heart Study, comprising 4552 women, to analyze the prevalence of self-reported asthma, asthma-like symptoms, and use of asthma medication in relation to treatment with exogenous female sex hormones.
Even after adjustments for age, smoking, and other factors, none of the asthma indicators was more prevalent among women using oral contraceptives than among other women, the authors report.
Similarly, among postmenopausal women, HRT was not associated with a higher prevalence of most asthma indicators, the report indicates, though HRT-treated women who had never smoked did have a higher prevalence of self-reported asthma and use of asthma medication.
"We have no information on women with surgical menopause," Dr. Lange told Reuters Health, "but I suspect that the results in this younger group should be similar."
"The most likely explanation for this discrepancy," the researchers speculate in the journal, "is that postmenopausal women on HRT are more likely to visit their GPs than women not on HRT and, if they are never-smokers, they are more likely to have their respiratory symptoms diagnosed as asthma and to receive asthma medication."
"There is no risk involved with regard to asthma in young women taking oral contraceptives," Dr. Lange said. "Although there may be a slightly increased risk connected with postmenopausal substitution, this risk was smaller in our study than previously reported in a US study."
"However," the authors conclude, "since this association was relatively weak, we think that further studies are needed and that present prescription policies in postmenopausal women do not yet need to be changed."
Thorax 2001;56:613-616.
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