Premenopausal fractures are associated with postmenopausal risk

המידע באדיבות medicontext.co.il
NEW YORK (Reuters Health) – A history of fracture–excluding those related to auto accidents–sustained between the ages of 20 and 50 years predicts a woman's risk of subsequent fractures after the age of 50 years, according to a report in the January 14th issue of the Archives of Internal Medicine.

Dr. Ian. R. Reid and colleagues, from the University of Auckland, New Zealand, examined the relation between self-reported fractures before and after age 50 years in a cross-sectional study of 1284 women who were at least 10 years postmenopausal. The investigators obtained detailed data on fractures, medical, menstrual, alcohol and smoking histories.

The researchers report that 494 women reported 721 fractures. One hundred eleven women (9%) reported fractures before age 20 years, 90 (7%) between the ages of 20 and 50 years, and 367 (29%) after age 50 years.

The odds ratio for fracture after age 50 years was 1.74 among women who sustained fractures between the ages of 20 and 50 years relative to those with no earlier fracture. No such association was observed among women who sustained fractures before age 20 years (odds ratio 1.01).

"Multivariate analysis showed that after bone density, age, maternal history of hip fractures, age at menopause, weight, history of hormone replacement therapy, and smoking and alcohol histories were adjusted for, a history of fractures between the ages of 20 and 50 years remained a significant independent predictor of risk of fractures after the age of 50 years (risk ratio, 1.83)," the investigators found.

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