Weight loss reduces C-reactive protein levels in overweight women

מתוך medicontext.co.il
NEW YORK (Reuters Health) – Levels of C-reactive protein (CRP), an independent risk factor for cardiovascular disease, fall when obese postmenopausal women lose weight, according to a report published in the February 5th issue of Circulation.

Dr. Eric T. Poehlman, from the University of Montreal, and colleagues measured the CRP levels of 61 obese postmenopausal women and found that the levels were directly related to total body fatness, measured by dual x-ray absorptiometry, and with the area of intraabdominal body fat, assessed by CT.

Twenty-five of the women completed a weight loss protocol and achieved an average weight loss of 14.5 kg. Significant reductions in fat mass, fat-free mass, visceral fat area, and subcutaneous fat area were noted (all p < 0.0001). Further analysis revealed that weight loss was associated with a significant reduction in CRP levels (p < 0.0001).

The results suggest that weight loss is an important means of reducing CRP levels in obese women and thereby improving their cardiovascular disease risk, the researchers state.

"The contribution of adipose tissue in interleukin-6 secretion has been proposed to be the link between plasma CRP and adiposity, as CRP synthesis in the liver is largely under the control of interleukin-6," the investigators note.

"Whether plasma CRP levels are related more closely to abdominal fat distribution than total body fatness per se remains to unclear at the present time," the authors point out. However, the current findings indicate that overall body fatness is a better predictor of plasma CRP levels.

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