Apolipoprotein E genotype associated with poor stroke outcome

מתוך medicontext.co.il
NEW YORK (Reuters Health) – In patients with subarachnoid hemorrhage, the apolipoprotein E genotype is associated with poor outcomes, according to a report in the February issue of Stroke: Journal of the American Heart Association.

In a prospective study, Dr. W. S. Poon, from the Chinese University of Hong Kong, and colleagues examined the relationship between apolipoprotein E genotype and the outcome of patients with subarachnoid hemorrhage. They evaluated the 6-month neurological outcome following discharge of 72 patients (mean age 58.3 years). Fifteen patients had the apolipoprotein E genotype (APOE4).

"At 6 months, 61 patients (84.7%) remained alive, 43 patients (59.7%) had a Glasgow Outcome Scale (GSO) score greater than 3, and 29 patients (40.3%) had a GOS score of 3 or less," the investigators report.

Univariate analysis showed that older patients were more likely to have a poor outcome at 6 months. Unfavorable outcome was also more likely to be seen in patients with poor Fisher's grade scores, poor World Federation of Neurological Surgeons grade scores and APOE4.

Dr. Poon's group found that "APOE4 remained significant in predicting outcome, after adjustment for other known risk factors."

"The results of this study demonstrate a clear relationship between APOE4 and poor outcome on aneurysmal subarachnoid hemorrhage." The investigators also point out that "this is the first prospective clinical study that [has] shown such a relationship."

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