Soy Isoflavone May Be Safe, Effective Alternative to Estrogen Replacement

NEW YORK (Reuters Health) Mar 04 – Daily soy isoflavone use significantly reduces menopausal symptoms in postmenopausal women and may also help prevent cardiovascular disease, according to a report published in the March issue of Obstetrics and Gynecology.
Furthermore, because isoflavones have estrogenic and anti-estrogenic effects depending on the target tissue, their use may not predispose to endometrial cancer as estrogen replacement therapy does.

Dr. Edmund C. Baracat and colleagues, from the Federal University of Sao Paulo in Brazil, randomized 80 postmenopausal women with climacteric symptoms to receive placebo or 100 mg of soy isoflavone daily for 4 months.

Isoflavone-treated women experienced a significant improvement (p < 0.01) in menopausal symptoms relative to baseline scores and to improvements in the placebo group, the investigators state.

Treatment with isoflavone was linked to a significant reduction in total cholesterol and LDL levels compared with baseline (p < 0.001) and the placebo group (p < 0.01), but appeared to have no effect on blood pressure, plasma glucose, HDL levels, and triglyceride levels. …

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