Lansoprazole Highly Effective In Healing Erosive Esophatigitis

LAKE FOREST, IL — February 28, 2002 — According to a new study, the proton pump inhibitors (PPIs) lansoprazole and esomeprazole are highly effective in healing erosive esophagitis. Lansoprazole is the number one prescribed PPI for new prescriptions in the United States.

The study, published in Clinical Drug Investigation, showed that the percentages of healed patients after an eight-week treatment cycle for lansoprazole 30 mg were 91.4 percent and for esomeprazole 40 mg were 89.1 percent. The percentages of heartburn-free patients (day or night) after one day, three days, and one week of treatment for lansoprazole were 34.5 percent, 27.3 percent, 23.1 percent, respectively and for esomeprazole were 27.3 percent, 22.3 percent, 18.7 percent, respectively. The differences seen in these results were not statistically significant.

"This study further establishes the power of lansoprazole in healing erosive esophagitis," said Colin Howden, M.D., professor of medicine, Northwestern University Medical School. "Lansoprazole's clinical experience and high healing rates should be considered when clinicians select a PPI."

Gastroesophageal reflux disease (GERD) is an often chronic disorder that may result in serious complications such as esophageal strictures and Barrett's esophagus. Heartburn is one of the most common symptoms of GERD and approximately 25 million Americans suffer from heartburn daily.

This randomized, double-blind, eight-week, multi-center trial compared the effectiveness of esomeprazole 40 mg with lansoprazole 30 mg in 284 patients with erosive esophagitis.

The primary efficacy measure was the healing of erosive esophagitis at week eight.
Patients recorded the presence and severity of daytime and nighttime heartburn in daily diaries. The most frequently reported adverse events in the study were diarrhea, eructation (belching) and headache.

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