Confocal Microscopy Detects Borders, Predicts Melanoma Progression

Laurie Barclay, MD

NEW YORK (MedscapeWire) March 11 — A new microscopy technique described in the February issue of the Journal of the American Academy of Dermatology allows border detection of skin cancers within living tissue.
"In vivo confocal microscopy can noninvasively image thin en face sections within living intact human tissue with high resolution and contrast," write Zeina S. Tannous and colleagues from Massachusetts General Hospital in Boston. "Living skin may be imaged with no discomfort and without the need for anesthesia or administration of exogenous dyes."

This case report of malignant melanoma in situ, lentigo maligna type, showed that the images seen in vivo by near-infrared reflectance confocal microscopy compared well with corresponding routine histopathologic sections.

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