Abnormal Low-Density Lipoprotein Particles Predominate In Untreated Hypertensives

Patients with untreated hypertension have a preponderance of smaller low-density lipoprotein subfractions which conventional lipid assays do not readily detect.

Low-density lipoprotein consists of particles which vary in size and electrophoretic mobility. A predominance of small, more mobile particles is a risk factor for cardiovascular disease.

Researchers at a specialist hypertension clinic in Birmingham, England, investigated untreated essential hypertensives to see if there might be abnormalities in their low-density lipoprotein subfractions.

After disc polyacrylamide gel electrophoresis, the researchers recorded the mean mobility (low-density lipoprotein locus) and heterogeneity (low-density lipoprotein spread) of mobility in 24 men and 17 women of mean age 52.6 years with untreated essential hypertension (but no vascular disease or diabetes). The specialists also recruited 22 male and 23 female controls of mean age 56.9 years.

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