Carefully selected patients who have localised prostate cancer and are treated by radical prostatectomy have a high rate of cure.
Researchers in the United States studied 906 patients who underwent radical prostatectomy for localised prostate cancer between 1990 and 1999. They aimed to determine the five-year and eight-year disease-specific and biochemical relapse-free survival, and the variables that predict biochemical failure.
They found that 43 percent of patients had extension of the disease outside the capsule, 44 percent had pathologic Gleason scores </= 6, 23 percent had positive margins, 8.9 percent had seminal vesicle invasion, and 1.9 percent had lymph node metastases. The five-year and eight-year cancer-specific survival rates were 97 and 95 percent respectively (follow-up mean was 44 months). Actuarial five-year and eight-year biochemical relapse-free survival rates were 81 and 76 percent, respectively.
Reports Dr Peter Clark, "Patients with organ-confined disease had a 100 percent cancer-specific survival rate and a 92 percent biochemical relapse-free survival rate at both five and eight years." Dr Clark is based at the Section of Urologic Oncology, Department of Urology, Cleveland Clinic Foundation, Cleveland, Ohio, USA.