NEW YORK (Reuters Health) Mar 15 – Low serum levels of 25-hydroxyvitamin D are associated with low bone mineral density in children who have been burned over more than 40% of their total body surface area, physicians in Texas and Chicago report.
Children with such severe burns are prone to osteopenia and bone fractures, Dr. Gordon L. Klein and associates note in the February issue of the Journal of Trauma Injury, Infection and Critical Care.
They determined lumbar spine bone mineral density and serum levels of vitamin D in two groups, each containing 12 children. In one group, the mean post-injury time was 7 years and in the other the mean post-injury time was 3 years. Three children in the 7-year group had developed fractures since their injuries, including one with multiple fractures.
Serum levels of 25-hydroxyvitamin D were below the low end of normal in 20 children. In contrast, 1,25-dihydroxyvitamin D levels were low in 5 of 11 children in the 7-year group, but in none of the 2-year group. Among children in the 7-year group, bone mineral density z-scores were directly correlated with serum levels of 25-hydroxyvitamin D.
Based on these findings, Dr. Klein, of the University of Texas Medical Branch in Galveston, and his colleagues conclude that vitamin D deficiency may occur in children who have experienced severe burns
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