IARS: Valve Surgeries: Inhaled Prostacyclin Aids Pulmonary Hypertension

SAN DIEGO, CA — March 21, 2002 — Adding nebulized prostacyclin after induction helps improve right ventricular function in patients with pulmonary hypertension undergoing repair of defective heart valves, suggest results presented here on March 18th at the 76th Clinical and Scientific Congress of the International Anesthesia Research Society.

Dr. Manon Hache of the Montreal Heart Institute in Canada, described the results of a study of 20 patients whose systolic pulmonary artery pressure was above 30 mm Hg, or whose mean pulmonary artery pressure exceeded 25 mm Hg.

The treatment with 60 µg of nebulized prostacyclin was safe and resulted in significant reduction of systolic pulmonary artery pressure, from 48.4 to 38.9 mm Hg, Dr. Hache said. The effect completely disappeared after 25 minutes. Right ventricular stroke work index also declined, from 10.7 to 7.8.g/mm2. Changes in platelet aggregation were not seen with the treatment.

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