Native Lung Physiology and Survival in Single Lung Transplant Patients

A DGReview of :"Bronchiolitis obliterans syndrome in single lung transplant recipients—patients with emphysema versus patients with idiopathic pulmonary fibrosis"
Journal of Heart and Lung Transplantation

By David Ball

Lung function and survival after single lung transplantation may be influenced by the recipients' lung physiology.

This suggests that the classification of bronchiolitis obliterans syndrome (BOS) should include disease specific characteristics, say researchers at the North West Lung Centre and the Department of Cardiothoracic Surgery, Wythenshawe Hospital, Manchester, England.

Following a lung transplant, BOS – as a disease of the small airways – is currently graded according to a decline in forced expiratory volume in 1 second (FEV1).

In this study, comparative changes in lung function and survival were evaluated in 31 patients with emphysema and 25 with idiopathic pulmonary fibrosis (IPF), all of whom had received single lung transplants and were at risk of BOS.

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