Terbinafine Restores Cell-Mediated Immunity to Trichophytin

NEW YORK (MedscapeWire) Mar 27 — The antifungal drug terbinafine can restore reactivity to trichophytin in patients with depressed cell-mediated immunity (CMI), according to a double-blind, placebo-controlled study reported in the March issue of the Journal of the American Academy of Dermatology.
"Terbinafine treatment enhances and restores CMI to intradermal trichophytin antigen in patients with Trichophyton rubrum onychomycosis and may thereby reduce susceptibility to reinfection," write Boni E. Elewski, MD, from the University of Alabama in Birmingham, and colleagues from the University Hospitals of Cleveland and Case Western Reserve University in Ohio.

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