Patients with inflammatory arthritis have a high prevalence of insulin resistance and dyslipidemia. Although this prevalence has been explained by the acute phase response and excess weight, no complete explanation was possible for the dyslipidemia.
A known association existed between rheumatoid arthritis (RA) and an increased mortality rate from cardiovascular disease. A possible correlation had also been previously reported between the acute phase response in RA and insulin resistance, and dyslipidemia.
Consequently, clinicians from Johannesburg Hospital at the University of Witwatersrand, Johannesburg, South Africa investigated the acute phase response for insulin resistance, dyslipidemia and excess weight in patients with inflammatory diabetes.