Higher calcium intake is associated with lower risk for distal colon cancer in both women and men.
United States researchers says the risk pattern they observed in two large, prospective cohorts is consistent with a threshold effect, "suggesting that calcium intake beyond moderate levels may not be associated with a further risk reduction."
They studied data on 87,998 women from the Nurses' Health Study (NHS) and 47,344 men from the Health Professionals Follow-up Study (HPFS). "Incremental benefit of additional calcium intake beyond approximately 700 milligrams per day appeared to be minimal," they concluded.
Investigators from Harvard University, Brigham and Women's Hospital and the Dana-Farber cancer Institute in Boston, Massachusetts had previously reported modest inverse associations between calcium intake and colorectal cancer risk separately in the NHS and HPFS populations.
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