Increased Plasminogenesis Found in Dermatitis Herpetiformis Patients

Medical Science Monitor

04/04/2002
By David Ball

Increased type 1 plasminogen activator inhibitor level (PAI-1) in patients with dermatitis herpetiformis (DH), a rare bullous dermatitis of autoimmune origin, may reflect a chronic inflammatory condition.

DH patients were found to have lower plasminogen and a-2 antiplasmin levels and increased concentrations of plasmin-alpha-2 antiplasmin (PAP) complexes. The findings suggest increased in vivo plasminogenesis among patients with DH, say researchers at the Medical University of Bydgoszcz, Poland.

The researchers measured indicators of fibrinolysis in 23 males and 10 females with DH compared to a healthy control group. The indicators included tissue plasminogen activator concentration (t-PA: Ag); urokinase plasminogen activator concentration (u-PA: Ag); plasminogen activator inhibitor concentration (PAI-Ag); plasminogen level; alpha-2 antiplasmin activity (a-2-AP); and PAP.

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