Chronic Hepatitis C in Israeli Children – מתוך כנס גאסטרו ילדים, 9 ביולי 2002


Efrat Broide,1 Shimon Reif,2 Eli Brazovski,3 Rivka Shapira,4 Batia Weiss,5 Hanoch Hager,6 Nurit Amir,7 and Yoram Bujanover5

Objectives: Natural history, epidemiology and histopathological features of chronic hepatis C (CHC) are well established in adults. Data on histopathological findings of CHC in children are still limited and controversial. We aimed to evaluate the histopathological features of CHC in children in Israel.

Methods: Twenty liver specimens from 20 children with CHC were reviewed retrospecively for inflammation and fibrosis. In addition, a semiquantitative assessment was performed for hepatocyte necrosis, fatty changes, cholestasis, bile duct damage, sinusoidal lymphocytosis and glycogen storage. Clinical and laboratory data were recorded from the charts.

Results: The most common histological feature was found to be portal inflammation (95%), followed by lobular inflammation (70%), usually mild. Sinusoidal lymphocytosis was present in 85% and glycogen storage vacuoles in 40%. Fibrosis was detected only in 20% of the children and no one had advanced stage of fibrosis or cirrhosis. No correlation was found between the age at biopsy and any of the histological parameters.

Conclusions: Children with CHC have a different phenotype of liver disease with less progressive natural history without relation to duration of the disease

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