EFFICACY OF HEPATITIS B VACCINATION – 8 YEARS AFTER INITIATING HBV VACCINATION OF INFANTS IN ISRAEL – מתוך כנס גאסטרו ילדים, 9 ביולי 2002

Shimon Reif, Raz Somech, Yohanan Peled ,Depatments of Pediatric gastroenterology,Gastroenterology, Tel-Aviv Souraski Medical Center

Hepatitis B vaccine has been proved to be highly effective inducing protection against HBV. Nevertheless, the duration of this protection is unknown, with titers of anti-HBV antibodies declining with time. The aim of this study was to asses the duration of immunity confered by primary course of the HBV vaccine. We measured antibody levels in 4 groups of 122 healthy children (ages 1-8 years) who were vaccinated against HBV. Seventy-seven percent of the children had protective (HbsAb titer=10 mIU/ml), and 48.4% were highly protective (>100), while 23% had no response to the vaccine (‹ 10 mIU/ml). We found that anti-HBV antibody titers declined over the years elapsing from vaccination (from 257.7 mIU/ml to 88.5 mIU/ml), with most of the reduction occuring in the group of 6-8 years after vaccination, 40% unresponsive Vs 17.4% in the group of 1-2 Years (p<0.01). There was no significant difference in anti-HBV titers in the first 5 years after vaccination (194.4 mIU/ml Vs 166.6 mIU/ml) . No correlation was was found between HbsAb titer and gestational age, birth weight and parental origin. However, females had higher titer than males 207.29mIU/ml Vs 141.86 (P<0.05). Our finding showed that reduction in levels of anti-HBs occurred during the years after primary immunization mainly 5 years after vaccination. Whether this titer decline correlates to immunologic memory needs further studies

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