כלכלת בריאות

Antioxidant use reduces efficacy of simvastatin-niacin therapy

מתוך אתר medicontext.co.il

WESTPORT, CT (Reuters Health) – In patients with coronary artery disease and low HDL cholesterol, supplementing simvastatin-niacin therapy with antioxidants does not alter the reduction in LDL cholesterol that typically occurs, but it does diminish the increase in HDL cholesterol.

Dr. Greg Brown and colleagues, from the University of Washington in Seattle, randomized 153 patients with CAD and low HDL cholesterol to receive simvastatin-niacin, antioxidants (vitamins E and C, beta-carotene, and selenium), simvastatin-niacin plus antioxidants, or placebo.

At 1 year, the placebo and antioxidant-only groups demonstrated minor changes in their lipid profiles, the authors state in the August issue of Atherosclerosis, Thrombosis, and Vascular Biology: Journal of the American Heart Association.

The two groups that received simvastatin-niacin demonstrated similar significant reductions in plasma cholesterol, triglyceride and LDL cholesterol levels. However, the group that received simvastatin-niacin alone showed much greater increases in HDL cholesterol levels, particularly HDL2 cholesterol, than the simvastatin-niacin plus antioxidants group.

In addition, simvastatin-niacin, but not simvastatin-niacin plus antioxidants, increased apolipoprotein A-I content in HDL particles and increased particle size.

"There have been a number of studies of antioxidants in populations that by and large haven't been taking lipid-lowering therapies," Dr. Brown told Reuters Health. "These studies have shown virtually no benefit from taking antioxidants in terms of preventing cardiovascular disease or cancer," he said.

Findings from early epidemiologic studies suggested that antioxidants might be beneficial, Dr. Brown noted. "However, a healthy user effect may have been occurring," he said. "It was the individuals who were healthy that were deciding to purchase and use antioxidants," he explained, not the other way around.

"I'm now telling patients who are on cholesterol-lowering drugs and have low HDL cholesterol to stop taking their antioxidant vitamins," Dr. Brown stated. "For other people taking antioxidant vitamins, I tell them that although antioxidants are unlikely to be harmful, there is no proven benefit either."

Arterioscler Thromb Vasc Biol 2001;21:1319-1325.

0 תגובות

השאירו תגובה

רוצה להצטרף לדיון?
תרגישו חופשי לתרום!

כתיבת תגובה

מידע נוסף לעיונך

כתבות בנושאים דומים

© ‫ e-Med
 כל הזכויות שמורות

 

התכנים המוצגים באתר זה מיועדים לאנשי צוות רפואי בלבד

אם כבר נרשמת, יש להקליד את פרטי הזיהוי שלך
עדיין לא נרשמת? באפשרותך לבצע רישום כאן
להרשמה לאתר