High levels of alanine aminotransferase (ALT) are associated with diminished hepatic insulin sensitivity and an increased risk of type 2 diabetes in high risk subjects, according to a report in the June issue of Diabetes. Previous studies have linked type 2 diabetes with elevated ALT levels, the authors explain, but none has examined measures of insulin resistance.
Dr. Barbora Vozarova and colleagues from the National Institutes of Health in Phoenix, Arizona studied ALT levels and changes in liver or whole-body insulin sensitivity, as well as the development of type 2 diabetes, in Pima Indians–a population with a high prevalence of insulin resistance and type 2 diabetes.
“Our study on ALT and its association with development of type 2 diabetes is part of a more general research effort in our group, led by Dr. Antonio Tataranni, to understand why obese people become resistant to the effect of insulin,” Dr. Vozarova told Reuters Health, “and why some of these obese, insulin-resistant people eventually develop type 2 diabetes.”
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