Predictors of CAD and stroke in diabetics identified

באדיבות מדיקונטקסט: Last Updated: 2001-07-19 13:22:17 EDT (Reuters Health)

WESTPORT, CT (Reuters Health) – In patients with type 2 diabetes mellitus, several factors are independently associated with the development of coronary artery disease and cerebrovascular disease, according to data from a prospective community-based study.

"Quantitative measurements for cholesterol, triglycerides, glucose, and lipoprotein(a)…were obtained from 1968 through 1982 from 449 patients who were free of CAD and cerebrovascular disease but had type 2 diabetes mellitus," Dr. Haitham S. Abu-Lebdeh and colleagues, from the Mayo Clinic, Rochester, Minnesota, explain in the July issue of Mayo Clinic Proceedings.

Two hundred sixteen CAD events and 115 cerebrovascular events occurred over a mean followup of 13 years. On multivariate analysis, significant predictors of future CAD events included age, fasting glucose levels, smoking, and triglycerides, with hazard ratios of 1.45, 1.63, 1.45, and 1.49, respectively.

Significant predictors of future cerebrovascular events included age, hypertension, fasting glucose levels, and smoking, with hazard ratios of 1.95, 1.89, 1.69, and 1.57, respectively.

"Medical attention should be directed toward altering the classic risk factors and the nonclassic risks, especially hyperglycemia and diabetic dyslipidemia," Dr. Abu-Lebdeh and colleagues conclude.

Mayo Clin Proc 2001;76:707-712.

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