Adverse lipid combinations do not have synergistic effect on heart disease risk


WESTPORT, CT (Reuters Health) – Increased levels of plasma triglycerides in combination with adverse levels of other lipids do not confer significantly greater risks of ischemic heart disease than that predicted from the independent effects of the lipids considered individually, British investigators report.

Dr. John W. G. Yarnell, of Queen's University of Belfast, and colleagues combined two cohorts of men examined between the ages of 45 and 63 years. Of 4362 men initially examined, 533 experienced a major ischemic heart disease event during the next 10 years.

Levels of triglycerides, high density lipoprotein (HDL) cholesterol, and total cholesterol were strongly associated with incident heart disease, the authors report in Arteriosclerosis, Thrombosis, and Vascular Biology: Journal of the American Heart Association for August.

The subjects were divided into 27 groups according to the tertiles of triglycerides, total cholesterol, and HDL cholesterol. "A comparison of the predicted number of events in the 27 groups with the number of events observed showed that a logistic regression provided an adequate fit without the need to incorporate interactions between lipids in the model," the investigators write.

Dr. Yarnell's team concludes that there is no interaction between the three lipids and the risk of ischemic heart disease.

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