NEW ORLEANS, LA — February 24, 2002 — A combination facial cream containing retinol and salicylic acid appears to reduce significantly both acne and signs of photo aging compared with a placebo vehicle.
Improvements in both parameters among patients who used the retinal and salicylic acid cream were seen as early as in the third week of use, according to the findings presented during a poster session yesterday here at the 60th annual meeting of the American Academy of Dermatology.
Dr. J. Leyden, lead investigator, from the department of dermatology, University of Pennsylvania, Philadelphia, and colleagues developed and tested the efficacy of a new combination facial cream containing stabilized all-trans-retinol 0.075% (vitamin A), salicylic acid 2%, pro-vitamin B5 and anti-oxidants versus placebo.
The 61 subjects were between the ages of 25 and 49 years of age and had either mild to moderate acne or mild to moderate signs of aging. They were instructed to apply the cream twice a day to the full face for eight weeks. At the end of the treatment period dermatologists graded the efficacy of the cream using a 10-point grading scale. …