NEW YORK (Reuters Health) Mar 01 – Apolipoprotein B (apoB) and small dense low-density lipoprotein (LDL) appear to be a better way to define familial combined hyperlipidemia (FCH) than current criteria, Dutch investigators suggest.
"FCH is characterized by a variable expression of hypercholesterolemia and/or hypertriglyceridemia," Dr. Mario J. Veerkamp and colleagues, from the University Medical Center Nijmegen, note in the February issue of Arteriosclerosis, Thrombosis, and Vascular Biology: Journal of the American Heart Association.
The researchers examined variability in lipid phenotype expression over a 5-year period in subjects from 32 families classified as having FCH based on total cholesterol and/or triglyceride levels exceeding the 90th percentile after adjustment for age and sex.
At the start of the study, 93 (31%) of the subjects were affected and 206 (69%) were unaffected relatives. Five years later, "a diagnosis of FCH was consistent in 69 (74%) of the 93 subjects," the team reports. Hence, 26% of the FCH subjects showed a sporadic normolipidemic pattern.
Among the 206 unaffected relatives at the start of the study, 28 (14%) developed an FCH lipid phenotype over 5 years. …