Hyaluronate Delays or Prevents Knee Replacement Surgery in Clinical Practice

NEW YORK (Reuters Health) Mar 05 – A single course of interarticular sodium hyaluronate (Hyalgan; FIDIA SpA) appears to be successful in relieving pain, delaying or preventing total knee replacement surgery, and improving quality of life for a majority of patients with moderate to severe osteoarthritis of the knee in a clinical practice setting.
Dr. John P. Barrett, from The Florida Knee and Orthopedics Center, Clearwater, and Dr. Paola Siviero, from FIDIA SpA, Padua, Italy, conducted an uncontrolled retrospective study of 249 patients treated with a single course of 5 interarticular hyaluronate injections during an 18 month. All the patients had moderate to severe osteoarthritis of the knee and were seen at a single orthopedic practice.

At 6 months' followup, the researchers judged 60.1% of the knees treated as having successfully responded to hyaluronate therapy. Only 20.3% of the knees needed total replacement, they report. …

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