Insulin May Help Prevent Thrombosis Leading to Heart Attack/Stroke

BUFFALO, NY — March 22, 2002 — Insulin may interfere with the cascade of reactions that promote clot formation and platelet aggregation in heart attack patients, and may help prevent clot formation and plaque development in persons at risk of heart attack and stroke according to new research by University at Buffalo (UB) endocrinologists.

The researchers have demonstrated that an infusion of insulin and glucose suppresses a factor that regulates genes for two pro-inflammatory proteins that promote coagulation and clot formation in smooth muscle tissue lining blood vessels.

Results of the study appear in the March issue of the Journal of Clinical Endocrinology and Metabolism.

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