AAD: Combination Gabapentin Plus Valacyclovir May Diminish Risk of Post-Herpetic Neuralgia

By Pamela Harrison

Special to DG News

NEW ORLEANS, LA — February 26, 2002 — The combination of the anticonvulsant gabapentin, the antiviral valacyclovir appears to diminishes greatly the risk of post-herpetic neuralgia following an acute herpes zoster outbreak compared with antiviral therapy alone.

Results from a study which compared valacyclovir plus gabapentin against antiviral monotherapy were presented here today during a poster session at the 60th annual meeting of the American Academy of Dermatology.

Dr. M.H. Brentjens and colleagues from the departments of dermatology, microbiology, immunology and medicine, at University of Texas Medical Branch, in Galveston, Texas, treated 30 patients who were at least 50 years of age with concomitant gabapentin 300 mg a day plus valacyclovir 1 g three times a day, for seven days. Treatment was initiated within 72 hours of vesicle or papule formation.

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