Frontiers in Cardiovascular Science

Eilat October 3-6, 2002

Agenda:

Thursday, October 3, 2002

14:00-14:30 – Opening

14:30-18:00 – Lipids and lipoprotein metabolism

19:30-20:30 – Keynote lecture

20:30-23:00 – South American Evening + Dinner – Sponsored by TEVA

Friday, October 4, 2002

08:00-11:00 – HDL and reverse cholesterol transport

11:00-11:30 – Coffee Break

11:30-14:00 – Genetics

14:00-15:00 – lunch

15:00-17:00 – Interventional Cardiology

19:30           – Dinner

Saturday, October 5, 2002

18:00-19:00 – Poster Session

19:30-20:30 – Keynote lecture

20:30-22:00 – Gala Dinner – Sponsord by HEOPHARM

                22:00             – Yaelim Folklore Group             

Sunday, October 6, 2002

08:00-11:00– Vascular wall Inflammation, oxidation and atherosclerosis

11:00-11:30 – Coffee Break

11:30-13:30 – Epidemiology of CVD

13:30-14:00 – Closing

Thursday, October 3, 2002

14:00-14:30 – Opening

Eran Leitersdorf

Neil Shachter

14:30-18:00 – Lipids and lipoprotein metabolism

Chairpersons:

Zemin Yao

Menachem Fainaru

Speakers:

14:30-15:00 Edward A. Fisher                          Multiple degradative pathways regulate the hepatic production of apolipoprotein B100

15:00-15:30 Henry N. Ginsberg                       Regulation of VLDL secretion by fatty acids

15:30-16:00 Sven-Olof Olofsson                      Mechanisms involved in the two steps of the VLDL assembly

16:00-16:30 Arthur A. Spector                           Polyunsaturated fatty acids and their bioactive products

16:30-17:00 – Coffee Break

17:00-17:30 Thomas Olivecrona                     Shlomo Eisenberg Lecture

17:30-18:00 Neil S. Shachter                            Metabolism of triglyceride-rich lipoproteins in the brain: Implications for Alzheimer’s Disease

18:00-18:30 Kevin Jon Williams                      Endocytosis via cell-surface proteoglycans: molecular determinants and pathways

19:30-20:30 – Keynote lecture

Chairpersons:

Gerald Brook

Max Maislos

Speaker:

Daniel Steinberg                 The Oxidative Modification Hypothesis: Where Do We Stand?

19:30-20:30 Lecture for accompanying persons: (in Hebrew) To eat in order to survive or to 

                       survive in orber to eat? By Reli Abel

20:30-23:00 – South American Evening + Dinner – Sponsored by TEVA.

Friday, October 4, 2002

08:00-11:00 – HDL and reverse cholesterol transport

Chairpersons:

Tony Hayek

Tova Chajek-Shaul

Speakers:

08:00-08:30 Olga Stein                                      Reverse cholesterol transport in vivo

08:30-09:00 Samir S. Deeb                              Hepatic Lipase: Genetics and role in lipoprotein metabolism and cardiovascular disease

09:00-09:30 Martijn B. Katan                             Dietary fats and CHD: the HDL paradox

09:30-10:00 Vardiella Meiner                            Increased 27-hydroxycholesterol Levels in Mice: New insight into the Roles of Oxysterols in Lipid Metabolism”

10:00-10:30 Richard J. Deckelbaum              Fatty acid-control of genes involved in cholesterol and triglyceride metabolism

10:30-11:00 Ira Tabas                                        The pathobiology of the free cholesterol-loaded macrophage

11:00-11:30 – Coffee Break

11:30-14:00 – Genetics

Chairpersons:

Samir Deeb

Hila Knobler

Speakers:

11:30-12:00 Mark Caulfield                               Genetics of human hypertension

12:00-12:30 Gustav Schonfeld                         Hypobetalipoproteinemia: genetics and metabolism

12:30-13:00 Zemin Yao                                     Non-truncation apoB mutations associated with Hypobetalipoproteinemia

13:00-13:30 Steve E. Humphries     Gene-environment interaction and risk of CAD

13:30-14:00 Joseph Witztum                            Innate Immune Responses to OxLDL

14:00-15:00 Lunch

15:00-16:00 – Interventional Cardiology

Chairpersons:

Ehud Grenadier

Ira j. Goldberg

Speakers:

15:00-15:30 Rafael Beyar                  The future of interventional Cardiology.

15:30-16:00 Judah Weinberger                       A role for coronary brachytherapy in the post-rapamycin stent era

16:00-17:00 Keynote lecture Sponsored by M.S.D.

Chairpersons:

Dror Harats

Yaakov Henkin

Speaker:

Klaus von Bergmann                          Inhibition of cholesterol absorption by Ezetimibe. New strategies for treatment of hypercholesterolemia

17:00-18:00 Business Meeting of the Israeli Atherosclerosis Society (full members only)

19:30 Dinner Kiddush by Dror Harats
Saturday, October 5, 2002

18:00-19:00 – Poster Session

Chairpersons:

Danny Yeshurun

Yechiel Friedlander

Young Investigator Award Committee:

Ishay Levy

Husain Osama

Dov Gavish

Danny Yeshurun

Yechiel Friedlander

19:30-20:30 – Keynote lecture

Chairpersons 

Ardon Rubinstein

Yitzhak Beigel

Speaker

Gerd Schmitz                        The role of ABC transporters in reverse cholesterol transport: effects on innate immunity and the prevention of Atherosclerosis

20:30-22:00 – GALA Dinner – Sponsored by NEOPHARM.

22:00 – Yaelim Folklore Group.

Sunday, October 6, 2002

08:00-11:00- Vascular wall Inflammation, oxidation, atherosclerosis

Chairpersons:

Kevin Jon Williams

Yechezkiel Stein

Speakers:

08:00-08:30 Jan Borיn                        Retention of atherogenic lipoproteins in atherogenesis

08:30-09:00 Michael Aviram              Paraoxonase protects against oxidative stress and atherosclerosis progression

09:00-09:30 Dror Harats                    Targeted gene therapy to the vascular wall

09:30-10:00 Roger A. Davis              Macrophage Expression of Paraoxonase-1 Reduces Induction of Inflammatory Genes and Atherosclerosis

10:00-10:30 Mohamad Navab          The use of HDL components as anti-inflammatory agents in atherosclerosis

10:30-11:00 Andrew Marks               Understanding why rapamycin works for stent restenosis where others have failed

11:00-11:30 – Coffee Break

11:30-14:00 Hadassah Workshop in the Epidemiology of CVD

Chairpersons:

David Siscovick

Uri Goldbourt

Speakers:

11:30-11:50 Ardon Rubinstein         The practice of cardiovascular disease prevention among Israeli physicians

11:50-12:20 David Siscovick             Polyunsaturated fats, fatty acids and atherosclerotic cardiovascular diseases

12:20-12:40 Jeremy Kark                  Characteristics of CHD in Israel

12:40-13:10 Jose M. Ordovas           Gene/Diet interactions determining plasma lipid levels and cardiovascular disease risk

13:10-13:30 Yaakov Henkin              The metabolic syndrome in ethnic subgroups in Israel

13:30-14:00 Philippa Talmud           Genetic control of plasma triglyceride levels

14:00-14:15 Closing

Eran Leitersdorf

Ardon Rubinstein

Neil Shachter

Richard Deckelbaum