אונקולוגיה

Chemoradiotherapy of long-term benefit in inoperable esophageal cancer

NEW YORK (Reuters Health) – Chemotherapy plus radiotherapy can produce "relatively good" long-term results in patients with inoperable squamous cell carcinoma of the esophagus, according to Italian researchers.

Dr. Paolo Bidoli, of the Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan, and colleagues conducted a prospective study of the survival of 101 patients with squamous cell carcinoma of the esophagus who were recruited over a 7-year period. The findings are featured in the January 15th issue of Cancer.

Patients were given two courses of treatment with cisplatin and fluorouracil and radiotherapy over a 19-day period. The chemotherapy and radiotherapy courses were then repeated in patients without potentially resectable tumors.

Altogether, 32 patients underwent surgery, and 7 (22%) died from surgical complications. No residual tumor was seen in 8 (25%), and microscopic foci only were seen in 12 (37%). Of 61 nonsurgical patients, 37 (61%) achieved complete clinical remission and 14 (23%) achieved partial remission.

Median survival for surgical patients was 15 months and for nonsurgical patients, 22 months. Overall, 83 of the patients died within 10 years. Survival at 5 years was 22% and had fallen to 12% by 10 years.

Among the nonsurgical patients, the tumor was located in the cervical esophagus in 32, and in 15 of these the larynx could be preserved. Ten-year disease-free survival in this group of 32 patients was 31%. These results, the investigators conclude, "suggest that an organ-sparing approach should be considered more often in such patients."

0 תגובות

השאירו תגובה

רוצה להצטרף לדיון?
תרגישו חופשי לתרום!

כתיבת תגובה

מידע נוסף לעיונך

כתבות בנושאים דומים

© ‫ e-Med
 כל הזכויות שמורות

 

התכנים המוצגים באתר זה מיועדים לאנשי צוות רפואי בלבד

אם כבר נרשמת, יש להקליד את פרטי הזיהוי שלך
עדיין לא נרשמת? באפשרותך לבצע רישום כאן
להרשמה לאתר