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Short Burst Tamoxifen Aids Fertility Among Breast Cancer Patients

Short-term use of tamoxifen for ovarian stimulation and embryo transfer or cryopreservation appears to be a feasible method of fertility preservation among breast cancer patients. Dr Kutluk Oktay and colleagues at the Center for Reproductive Medicine and Infertility, Weill Medical College of Cornell University, New York, United States, undertook this study investigating the role of tamoxifen and fertility.

They found that among 12 breast cancer survivors, stimulating the ovaries with a short, carefully timed course of tamoxifen boosted the number of retrievable mature oocytes. One woman in their study had two fresh embryos transferred and has given birth to twins, they report. “Sometimes the best ideas are the obvious ones and tamoxifen seemed the obvious choice of drug to test, although, to my knowledge, no one has tried it before in breast cancer patients,” Dr Oktay said in a comment on the study.

 “We hypothesised that tamoxifen stimulation would result in higher numbers of embryos compared with natural cycle in vitro fertilization (IVF), while theoretically shielding breast cancer cells against oestrogen.”

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