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Mild to Moderate PID Responds to Outpatient Antibiotics


Laurie Barclay, MD NEW YORK (MedscapeWire) May 17 —

Women with mild to moderate pelvic inflammatory disease (PID) can be treated successfully as outpatients, according to results of a study published in the May issue of the American Journal of Obstetrics and Gynecology. Fertility rates and other long-term outcomes were comparable to those of women hospitalized for treatment. “Until now, doctors have used idiosyncratic rules to determine which patients need to be hospitalized for PID,” principal investigator Roberta Ness, MD, MPH, from the University of Pittsburgh, Pennsylvania, says in a news release.

“These data are the first to help doctors make that determination more rationally.” In the multicenter PID Evaluation and Clinical Health (PEACH) trial, 831 women with PID were randomized to either inpatient or outpatient antibiotic treatment for 14 days.

 Inpatient treatment was initiated with intravenous cefoxitin and doxycycline, and outpatient treatment consisted of a single intramuscular injection of cefoxitin and oral doxycycline. About three-quarters of the women were African American, and about three-quarters had an educational level of high school or less.

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