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CPS: Oral Salbutamol Ineffective for Acute Viral Bronchiolitis in Infants

TORONTO, ON — June 14, 2002 —

Oral salbutamol for the treatment of acute viral bronchiolitis in infants may not be as effective or appropriate as physicians think.

Infants brought to the emergency department are commonly put on a course of the drug, yet there is little evidence to support its use, said Dr. Hema Patel, of the Montreal Children’s Hospital, Montreal, Quebec, Canada. She presented the findings here at the 79th Annual Meeting of the Canadian Paediatric Society (CPS) here.

 “Acute viral bronchiolitis is the most common lower respiratory tract infection of infancy and occurs in epidemic fashion every winter,” she said, adding that large numbers of cases typically show up in emergency departments each year.

 Survey studies and pharmacy prescription databases reveal that oral bronchodilators are commonly prescribed for this patient group, with salbutamol frequently being prescribed three times daily for five to seven days.

 “Even though it is commonly used, we were only able to find two previously published trials that examined the effects of oral bronchodilators in infants with acute bronchiolitis,” Dr. Patel said. This triggered researchers to do a randomised, controlled trial to see whether therapy with the oral bronchodilator was more effective than no treatment at all.

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