ההשוואה הראתה שוני גדול בין השטיפות . השילוב של CHX plus 0.05% CPC הראה את התוצאות הטובות ביותר . לצערינו בארץ עדין אין את מרבית השילובים אשר נבדקו במחקר . Journal Of Clinical Periodontology Comparative effects of different chlorhexidine mouth-rinse formulations on volatile sulphur compounds and salivary bacterial counts Silvia Roldán1, David Herrera1,2, Isabel Santa-Cruz1, Ana O’Connor2, Itziar González2 and Mariano Sanz1,2 Aim: To compare five different commercial mouth rinses with chlorhexidine (CHX) with respect to their anti-halitosis effect and anti-microbial activity on salivary bacterial counts, following a standardised research protocol. And secondly, to validate the study model proposed in the evaluation of patients suffering from halitosis. Patients and Methods: Ten volunteers, with a healthy oral status, were enrolled in a double-blind, cross-over design, using sterile saline as negative control and five CHX-containing mouth rinses: 0.12% CHX alone (CHX+NO), plus alcohol (CHX+ALC), plus 0.05% cetylpiridinium chloride (CHX+CPC), plus sodium fluoride (CHX+NaF), and 0.05% CHX plus 0.05% CPC, plus 0.14% zinc lactate (CHX+Zn). The levels of whole-mouth volatile sulphur compounds (VSCs) were measured by means of a sulphide monitor at baseline, 1 and 5 h after rinsing with the assigned product. Baseline measurements also included an organoleptic assessment and the recording of the tongue-coating index. Aerobic and anaerobic salivary bacterial counts were also obtained by collecting unstimulated saliva samples at the same evaluation times, and processed by culturing techniques. Analysis of variance was used to evaluate whether significant differences existed among groups, at each evaluation point, or in changes between evaluations. Results: No significant differences were detected at baseline, with VSC levels ranging between 190 and 227 parts per billion (p.p.b.) After rinsing, VSC levels were reduced with all products (except saline), after 1 h. Significant differences at 1 h were detected (p=0.04), corresponding to a lower amount of p.p.b. (109) in (CHX+Zn) as compared with the other groups (except CHX+NO). At 5 h, VSC levels were lower for CHX+CPC and CHX+Zn (155 and 169, respectively), while the other groups showed levels higher than 220 p.p.b. With respect to aerobic salivary bacterial counts, CHX+CPC demonstrated the lowest percentage of survival (6% after 1 h and 18% after 5 h). For anaerobic bacterial counts, again CHX+CPC demonstrated the lowest percentage of survival (10% at 1 h and 23% at 5 h), together with CHX+ALC (18% of survival at 5 h). However, salivary counts and VSCs were only significantly correlated at baseline, but not after treatment. Conclusion: Important differences can be expected from different CHX formulations, in relation to both their anti-halitosis effect and anti-microbial activity in saliva. Formulations that combine CHX and CPC achieved the best results, and a formulation combining CHX with NaF resulted in the poorest. |
ארקוקסיה יעילה בשיכוך כאבים לאחר ניתוח עקירת שן (Clinical Journal of Pain)
התרופה etoricoxib (ארקוקסיה) היתה יעילה בשיכוך כאבים והועדפה על ידי מטופלים לאחר עקירת שן בהשוואה לפלצבו ולקומבינציה של אצטמינופן וקודאין, כך לפי מחקר חדש שפורסם ב-Clinical Journal of Pain. מטרת המחקר היתה להעריך את ההשפעה משככת הכאב של תרופת ה- etoricoxib ושל תרופות מתחרות ביום השני והשלישי שלאחר ניתוח עקירה. במחקר השתתפו 588 מטופלים, שחולקו […]
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