NEW YORK (Reuters Health) – Treatment of photodamaged facial skin with tazarotene cream is safe and effective, with only mild to moderate local adverse effects, researchers report.
Dr. Sewon Kang from the University of Michigan Medical Center, Ann Arbor, and colleagues randomized 349 subjects with photodamaged facial skin to 24 weeks of daily treatment with tazarotene cream (0.01%, 0.025%, 0.05% and 0.1%) or its inactive vehicle cream or 0.05% tretinoin cream.
Both tazarotene cream and tretinoin significantly improved mottled hyperpigmentation and fine wrinkles, according to the report in the December issue of the Archives of Dermatology.
At week 24, the success rate for tazarotene cream ranged from 67% with the 0.1% concentration to 36% with the 0.025% concentration. The global success rate was 41%. For tretinoin the global success rate was 55% and for the vehicle it was 23%, the researchers report.
Dr. Kang and colleagues conclude that "tazarotene cream reduces the severity of fine wrinkles and mottled hyperpigmentation and ameliorates the overall condition of photodamaged skin when compared with treatment with inactive vehicle cream."
"Overall, 0.1% tazarotene cream had the best efficacy of the four tazarotene concentrations evaluated. For local irritation, tazarotene was reasonably well tolerated, although somewhat more irritating at higher concentrations."