MI outcomes similar for men and women treated with a reperfusion strategy

NEW YORK (Reuters Health) – Even though women with acute myocardial infarction tend to be older than men, and to have more diabetes or hypertension, their outcomes are similar when reperfused via percutaneous coronary intervention, according to a report in the January 9th issue of The Journal of the American Medical Association.

Dr. Adnan Kastrati, of Deutsches Herzzentrum, Munich, Germany, and colleagues examined the impact of patient's sex on mortality 1 year after acute MI in 502 women and 1435 men.

Women were older than men, at 70 years and 61 years, respectively (p < 0.001), and had a greater prevalence of diabetes or hypertension. "Both men and women received essentially identical therapy with the majority of patients (86%) receiving reperfusion therapy via percutaneous coronary interventions," the team explains.

They found no significant differences between men and women in 30-day event rates. They note that 6.2% of the women required revascularization of the infarct-related artery within the 30 days of treatment, compared with 7.2% of the men.

The investigators observed no significant differences in 1-year mortality rates between the groups (13.8% among women versus 12.9% among men; unadjusted hazard ratio 1.06). Women had a lower risk of death after adjustment for age (hazard ratio 0.65; p = 0.004).

"Our results suggest that sex alone should not be a factor in deciding whether to perform primary percutaneous coronary interventions," Dr. Kastrati and colleagues conclude

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