Body Composition Altered in Chronic Renal Insufficiency

NEW YORK (Reuters Health) Mar 13 – Patients with moderate chronic renal insufficiency show signs of protein-calorie malnutrition, but the cause remains an enigma, according to a report in the February issue of the American Journal of Kidney Diseases.
Malnutrition is an important prognostic factor in dialysis patients, the authors explain, and some observations suggest that nutritional status in chronic renal insufficiency (CRI) deteriorates even before dialysis becomes necessary.

Dr. Anthony O'Sullivan and colleagues from St. George Hospital and University of New South Wales in Sydney, Australia compared the body composition and energy metabolism in 15 CRI patients with that in 15 healthy control subjects.

CRI patients had significantly lower lean body mass, bone mineral density, and total body bone mineral content than did healthy controls, the authors report, though fat body mass and total body bone mineral calcium were not significantly different.

Although total daily protein intake was lower in CRI patients, the report indicates, the total energy intake did not differ between the CRI and control groups.

Basal energy expenditure was significantly lower in CRI patients, the researchers note, but there were no detectable differences in basal respiratory quotient, carbohydrate oxidation rates, or lipid oxidation rates between the two groups.

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