Captopril improves left ventricular diastolic dysfunction (LVDD) among people with type 1 diabetes and concurrent microalbuminuria.
Diabetic cardiomyopathy is more common in patients with diabetes mellitus with microalbuminuria than those without the latter complication. LVDD might offer an early marker of diabetic cardiomyopathy. Against this background, researchers from the Complejo Hospitalario Universitario de Albacete, in Albacete, Spain, enrolled 18 men and 12 women with type 1 diabetes, who were <40 years of age and had been diagnosed recently with microalbuminuria.
Baseline echocardiograms identified 11 patients with normal diastolic function and 19 with LVDD. After six months of captopril treatment, the early filling rate peak/late filling rate peak ratio improved in both groups. Isovolumetric relaxing time improved in patients with LVDD.